› 4erv

X-ray diffraction
1.75Å resolution

Crystal structure of human ryanodine receptor 3 (2597-2800)

Released:
DOI: 10.2210/pdb4erv/pdb
PDB entry 4erv coloured by chain, front view.
PDB entry 4erv coloured by chain, side view.
PDB entry 4erv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Disease mutations in the ryanodine receptor central region: crystal structures of a phosphorylation hot spot domain.
Yuchi Z, Lau K, Van Petegem F
Structure 20 1201-11 (2012)
PMID: 22705209

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-172280 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ryanodine receptor 3 Chain: A
Molecule details ›
Chain: A
Length: 207 amino acids
Theoretical weight: 23.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15413 (Residues: 2597-2800; Coverage: 4%)
Gene names: HBRR, RYR3
Sequence domains: RyR domain
Structure domains: Globin-like

Ligands and Environments

2 bound ligands:
Ligand SO4 3 x SO4
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: C2
Unit cell:
a: 93.57Å b: 58.54Å c: 47.46Å
α: 90° β: 97.21° γ: 90°
R-values:
R R work R free
0.191 0.19 0.22
Expression system: Escherichia coli

Quick links

Citations

29 review citations

Ryanodine receptors: structure and function.
Van Petegem F. (2012)
28 more

1 mention without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)