› 4el9

X-ray diffraction
1.55Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148420 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribosomal protein S6 kinase alpha-3 Chain: A
Molecule details ›
Chain: A
Length: 305 amino acids
Theoretical weight: 35.07 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P18654 (Residues: 45-346; Coverage: 41%)
Gene names: Mapkapk1b, Rps6ka-rs1, Rps6ka3, Rsk2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand AFE 1 x AFE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: C2
Unit cell:
a: 99.119Å b: 40.86Å c: 83.867Å
α: 90° β: 114.64° γ: 90°
R-values:
R R work R free
0.226 0.2 0.226
Expression system: Escherichia coli

Quick links

Citations

4 review citations

A review of ligand-based virtual screening web tools and screening algorithms in large molecular databases in the age of big data.
Banegas-Luna et al. (2018)
3 more

6 mentions without citation

The unusual mechanism of inhibition of the p90 ribosomal S6 kinase (RSK) by flavonol rhamnosides.
Utepbergenov et al. (2013)
5 more