› 4e6z

X-ray diffraction
2.15Å resolution

Tic22 from Plasmodium falciparum

Released:
DOI: 10.2210/pdb4e6z/pdb
PDB entry 4e6z coloured by chain, front view.
PDB entry 4e6z coloured by chain, side view.
PDB entry 4e6z coloured by chain, top view.
Source organism: Plasmodium falciparum 3D7
Primary publication:
Tic22 is an essential chaperone required for protein import into the apicoplast.
Glaser S, van Dooren GG, Agrawal S, Brooks CF, McFadden GI, Striepen B, Higgins MK
J Biol Chem 287 39505-12 (2012)
PMID: 23027875

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184658 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apicoplast TIC22 protein Chain: A
Molecule details ›
Chain: A
Length: 279 amino acids
Theoretical weight: 34.04 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8I3H4 (Residues: 1-279; Coverage: 100%)
Gene name: PF3D7_0529300
Sequence domains: Tic22-like family
Structure domains: Trna Endonuclease; Chain: A, domain 1

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
1 modified residue:
Ligand MSE 11 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P41212
Unit cell:
a: 66.25Å b: 66.25Å c: 129.37Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.217 0.242
Expression system: Escherichia coli

Quick links

Citations

19 review citations

New insights into the mechanism of chloroplast protein import and its integration with protein quality control, organelle biogenesis and development.
Paila et al. (2015)
18 more

3 mentions without citation

Tic22 is an essential chaperone required for protein import into the apicoplast.
Glaser et al. (2012)
2 more