› 4dwn

X-ray diffraction
1.58Å resolution

Crystal Structure of Human BinCARD CARD

Released:
DOI: 10.2210/pdb4dwn/pdb
PDB entry 4dwn coloured by chain, front view.
PDB entry 4dwn coloured by chain, side view.
PDB entry 4dwn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized.
Chen KE, Richards AA, Caradoc-Davies TT, Vajjhala PR, Robin G, Lua LH, Hill JM, Schroder K, Sweet MJ, Kellie S, Kobe B, Martin J
Acta Crystallogr D Biol Crystallogr 69 774-84 (2013)
PMID: 23633586

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188625 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Caspase recruitment domain-containing protein 19 Chains: A, B
Molecule details ›
Chains: A, B
Length: 100 amino acids
Theoretical weight: 11.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96LW7 (Residues: 3-99; Coverage: 43%)
Gene names: C9orf89, CARD19
Structure domains: Death Domain, Fas

Ligands and Environments

1 bound ligand:
Ligand SO4 3 x SO4
1 modified residue:
Ligand CSO 2 x CSO

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: P1
Unit cell:
a: 32.088Å b: 36.513Å c: 43.75Å
α: 108.5° β: 90.29° γ: 111.13°
R-values:
R R work R free
0.165 0.163 0.197
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

The versatile roles of CARDs in regulating apoptosis, inflammation, and NF-κB signaling.
Kao et al. (2015)
6 other articles

2 mentions without citation

Assembly of platforms for signal transduction in the new era: dimerization, helical filament assembly, and beyond.
Ha et al. (2020)
1 more