› 4cye

X-ray diffraction
3.2Å resolution

Crystal structure of avian FAK FERM domain FAK31-405 at 3.2A

Released:
DOI: 10.2210/pdb4cye/pdb
PDB entry 4cye coloured by chain, front view.
PDB entry 4cye coloured by chain, side view.
PDB entry 4cye coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Phosphatidylinositol 4,5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes.
Goñi GM, Epifano C, Boskovic J, Camacho-Artacho M, Zhou J, Bronowska A, Martín MT, Eck MJ, Kremer L, Gräter F, Gervasio FL, Perez-Moreno M, Lietha D
Proc Natl Acad Sci U S A 111 E3177-86 (2014)
PMID: 25049397

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169484 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Focal adhesion kinase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 375 amino acids
Theoretical weight: 43.01 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q00944 (Residues: 31-405; Coverage: 36%)
Gene names: FAK, FAK1, PTK2
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 43.934Å b: 146.128Å c: 69.052Å
α: 90° β: 96.98° γ: 90°
R-values:
R R work R free
0.176 0.173 0.24
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

28 review citations

FAK signaling in human cancer as a target for therapeutics.
Lee et al. (2015)
27 more

2 mentions without citation

Phosphatidylinositol 4,5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes.
Goñi et al. (2014)
1 more