› 4clj

X-ray diffraction
1.66Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193961 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ALK tyrosine kinase receptor Chain: A
Molecule details ›
Chain: A
Length: 327 amino acids
Theoretical weight: 36.93 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9UM73 (Residues: 1093-1411; Coverage: 20%)
Gene name: ALK
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 5P8 1 x 5P8
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 51.754Å b: 57.587Å c: 104.887Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.196 0.229
Expression system: Spodoptera frugiperda

Quick links

Citations

104 review citations

Understanding and targeting resistance mechanisms in NSCLC.
Rotow et al. (2017)
103 more

4 mentions without citation

Molecular Anatomy of the EML4-ALK Fusion Protein for the Development of Novel Anticancer Drugs.
Cheon et al. (2023)
3 more