› 4cai

X-ray diffraction
2.2Å resolution

Structure of inner DysF domain of human dysferlin

Released:
DOI: 10.2210/pdb4cai/pdb
PDB entry 4cai coloured by chain, front view.
PDB entry 4cai coloured by chain, side view.
PDB entry 4cai coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of the human Dysferlin inner DysF domain.
Sula A, Cole AR, Yeats C, Orengo C, Keep NH
BMC Struct Biol 14 3 (2014)
PMID: 24438169

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo trimer
Assembly name:
PDBe Complex ID:
PDB-CPX-131173 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dysferlin Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 112 amino acids
Theoretical weight: 13.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O75923 (Residues: 942-1052; Coverage: 5%)
Gene names: DYSF, FER1L1

Ligands and Environments

1 bound ligand:
Ligand PO4 3 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P212121
Unit cell:
a: 79.894Å b: 77.473Å c: 74.504Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.186 0.227
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

The Role of Autophagy in Skeletal Muscle Diseases.
Xia et al. (2021)
5 more

1 mention without citation

Crystal structures of the human Dysferlin inner DysF domain.
Sula et al. (2014)