› 4b87

X-ray diffraction
2.16Å resolution

Crystal structure of human DNA cross-link repair 1A

Released:
DOI: 10.2210/pdb4b87/pdb
PDB entry 4b87 coloured by chain, front view.
PDB entry 4b87 coloured by chain, side view.
PDB entry 4b87 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Allerston CK, Berridge G, Carpenter EP, Kochan G, Krojer T, Mahajan P, Vollmar M, Yue WW, Arrowsmith CH, Edwards A, Bountra C, von Delft F, Gileadi O

Function and Biology Details

Reaction catalysed: 
A beta-lactam + H(2)O = a substituted beta-amino acid
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180185 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA cross-link repair 1A protein Chain: A
Molecule details ›
Chain: A
Length: 367 amino acids
Theoretical weight: 41.38 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q6PJP8 (Residues: 676-1040; Coverage: 35%)
Gene names: DCLRE1A, KIAA0086, SNM1, SNM1A
Sequence domains: DNA repair metallo-beta-lactamase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand ZN 1 x ZN
Ligand EDO 4 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P6122
Unit cell:
a: 83.4Å b: 83.4Å c: 257.841Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.178 0.176 0.218
Expression system: Not provided

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