› 4avx

X-ray diffraction
1.68Å resolution

Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate (Hgs-Hrs) bound to an IP2 compound at 1.68 A Resolution

Released:
DOI: 10.2210/pdb4avx/pdb
PDB entry 4avx coloured by chain, front view.
PDB entry 4avx coloured by chain, side view.
PDB entry 4avx coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Williams E, Canning P, Shrestha L, Krojer T, Vollmar M, Slowey A, Conway S, von Delft F, Arrowsmith CH, Edwards AM, Weigelt J, Bountra C, Bullock A

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127226 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hepatocyte growth factor-regulated tyrosine kinase substrate Chain: A
Molecule details ›
Chain: A
Length: 226 amino acids
Theoretical weight: 26.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O14964 (Residues: 1-225; Coverage: 29%)
Gene names: HGS, HRS
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand EDO 8 x EDO
Ligand ZN 2 x ZN
Ligand ITP 1 x ITP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P21
Unit cell:
a: 27.825Å b: 67.545Å c: 57.423Å
α: 90° β: 103.51° γ: 90°
R-values:
R R work R free
0.184 0.181 0.231
Expression system: Escherichia coli BL21

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