› 4aqb

X-ray diffraction
4.2Å resolution

MBL-Ficolin Associated Protein-1, MAP-1 aka MAP44

Released:
DOI: 10.2210/pdb4aqb/pdb
PDB entry 4aqb coloured by chain, front view.
PDB entry 4aqb coloured by chain, side view.
PDB entry 4aqb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure and functional characterization of the complement regulator mannose-binding lectin (MBL)/ficolin-associated protein-1 (MAP-1).
Skjoedt MO, Roversi P, Hummelshøj T, Palarasah Y, Rosbjerg A, Johnson S, Lea SM, Garred P
J Biol Chem 287 32913-21 (2012)
PMID: 22854970

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155806 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Mannan-binding lectin serine protease 1 heavy chain Chain: A
Molecule details ›
Chain: A
Length: 361 amino acids
Theoretical weight: 41.46 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P48740 (Residues: 20-379; Coverage: 53%)
Gene names: CRARF, CRARF1, MASP1, PRSS5
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
1 bound ligand:
Ligand CA 6 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P4322
Unit cell:
a: 94.15Å b: 94.15Å c: 242.57Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.28 0.279 0.301
Expression system: Cricetulus griseus

Quick links

Citations

10 review citations

Pattern recognition receptors in health and diseases.
Li et al. (2021)
9 more

5 mentions without citation

Structure and activation of C1, the complex initiating the classical pathway of the complement cascade.
Mortensen et al. (2017)
4 more