› 457d

X-ray diffraction
2Å resolution

MOLECULAR AND CRYSTAL STRUCTURE OF D(CGCGMO6AATTCGCG): N6-METHOXYADENOSINE/ THYMIDINE BASE-PAIRS IN B-DNA

Released:
DOI: 10.2210/pdb457d/pdb
PDB entry 457d coloured by chain, front view.
PDB entry 457d coloured by chain, side view.
PDB entry 457d coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Crystallographic studies on damaged DNAs. II. N(6)-methoxyadenine can present two alternate faces for Watson-Crick base-pairing, leading to pyrimidine transition mutagenesis.
Chatake T, Hikima T, Ono A, Ueno Y, Matsuda A, Takénaka A
J Mol Biol 294 1223-30 (1999)
PMID: 10600380

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-117162 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*CP*GP*CP*GP*(A47)P*AP*TP*TP*CP*GP*CP*G)-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 12 nucleotides
Theoretical weight: 3.69 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand MG 1 x MG
1 modified residue:
Ligand A47 2 x A47

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P212121
Unit cell:
a: 24.9Å b: 39.5Å c: 66.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.238 0.232 0.285
Expression system: Not provided

Quick links

Citations

10 citation in other articles

Thymine-methyl/pi interaction implicated in the sequence-dependent deformability of DNA.
Umezawa et al. (2002)
9 more

1 mention without citation

A reproducible picture of open access health facility data in Africa and R tools to support improvement.
South et al. (2020)