› 3zzw

X-ray diffraction
2.9Å resolution

Crystal structure of the kinase domain of ROR2

Released:
DOI: 10.2210/pdb3zzw/pdb
PDB entry 3zzw coloured by chain, front view.
PDB entry 3zzw coloured by chain, side view.
PDB entry 3zzw coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Tresaugues L, Moche M, Arrowsmith CH, Berglund H, Bountra C, Edwards AM, Ekblad T, Graslund S, Karlberg T, Nyman T, Schuler H, Thorsell AG, Weigelt J, Nordlund P, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169655 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase transmembrane receptor ROR2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 289 amino acids
Theoretical weight: 33.07 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q01974 (Residues: 463-751; Coverage: 32%)
Gene names: NTRKR2, ROR2
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand CL 1 x CL
Ligand SO4 4 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P21
Unit cell:
a: 55.613Å b: 61.301Å c: 79.936Å
α: 90° β: 93.07° γ: 90°
R-values:
R R work R free
0.19 0.187 0.247
Expression system: Spodoptera frugiperda

Quick links