3znc Summary

pdbe.org/3znc
spacer

MURINE CARBONIC ANHYDRASE IV COMPLEXED WITH BRINZOLAMIDE

The structure was published by Stams, T., Chen, Y., Boriack-Sjodin, P.A., et al., Laipis, P., Silverman, D.N., and Christianson, D.W., in 1998 in a paper entitled "Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: molecular basis of isozyme-drug discrimination." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 1998.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE IV. This molecule has the UniProt identifier Q64444 (CAH4_MOUSE)search. The sample contained 258 residues which is 90% of the natural sequence. Out of 258 residues 249 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE IV Q64444 (22-279) (CAH4_MOUSE)search Mus musculussearch 90% 258 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q64444 (22 - 279) CARBONIC ANHYDRASE IV Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q64444) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (Q64444) carbonate dehydratase activitysearch protein bindingsearch zinc ion bindingsearch lyase activitysearch metal ion bindingsearch plasma membranesearch sarcoplasmic reticulumsearch secretory granule membranesearch anchored component of membranesearch membranesearch endoplasmic reticulum-Golgi intermediate compartmentsearch sarcolemmasearch extracellular vesicular exosomesearch anchored component of external side of plasma membranesearch brush border membranesearch apical plasma membranesearch anchored component of plasma membranesearch perinuclear region of cytoplasmsearch Golgi apparatussearch cell surfacesearch rough endoplasmic reticulumsearch trans-Golgi networksearch transport vesicle membranesearch organ developmentsearch one-carbon metabolic processsearch regulation of pHsearch carbon dioxide transportsearch bicarbonate transportsearch response to drugsearch response to steroid hormonesearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase, CA4search Carbonic anhydrase, alpha-classsearch