3zmi Summary

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Structure of E.coli rhomboid protease GlpG in complex with monobactam L29

The structure was published by Vinothkumar, K.R., Pierrat, O.A., Large, J.M., and Freeman, M., in 2013 in a paper entitled "Structure of Rhomboid Protease in Complex with Beta-Lactam Inhibitors Defines the S2' Cavity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of RHOMBOID PROTEASE GLPG. This molecule has the UniProt identifier P09391 (GLPG_ECOLI)search. The sample contained 179 residues which is < 90% of the natural sequence. Out of 179 residues 173 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A RHOMBOID PROTEASE GLPG P09391 (92-270) (GLPG_ECOLI)search Escherichia coli K-12search < 90% 179 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P09391 (92 - 270) RHOMBOID PROTEASE GLPG Escherichia coli

Chain Sequence family (Pfam)
A Rhomboid familysearch, Protein of unknown function (DUF3582)search

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P09391) integral component of membranesearch serine-type endopeptidase activitysearch proteolysissearch

Chain InterPro annotation
A Peptidase S54, rhomboidsearch Peptidase S54, rhomboid domainsearch Rhomboid protease GlpGsearch