spacer Structure of E.coli rhomboid protease GlpG in complex with monobactam L62
Accession P09391search
Keywords Transmembrane, Serine protease, Cell membrane, 3D-structure, Cell inner membrane, Transmembrane helix, Membrane, Protease, Reference proteome, Complete proteome, Direct protein sequencing, Hydrolase
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Polymers A
Enzyme nomenclature
EC number ExPASy BRENDA search
Polymers A
Name rhomboid protease
Comment These endopeptidases are multi-spanning membrane proteins. Their catalytic site is embedded within the membrane and they cleave type-1 transmembrane domains. A catalytic dyad is involved in proteolysis rather than a catalytic triad, as was thought previously. They are important for embryo development in Drosophila melanogaster. Rhomboid is a key regulator of EGF receptor signalling and is responsible for cleaving Spitz, the main ligand of the Drosophila EGF receptor pathway. Belongs in peptidase family S54. Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite. Rhomboids are widely conserved from bacteria to archaea to humans [9,13].