3zlx Summary


Crystal structure of MEK1 in complex with fragment 18

The structure was published by Amaning, K., Lowinski, M., Vallee, F., et al., Llopart, S., Halland, N., and Rak, A., in 2013 in a paper entitled "The Use of Virtual Screening and Differential Scanning Fluorimetry for the Rapid Identification of Fragments Active Against Mek1." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1. This molecule has the UniProt identifier Q02750 (MP2K1_HUMAN)search. The sample contained 348 residues which is < 90% of the natural sequence. Out of 348 residues 309 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 Q02750 (37-383) (MP2K1_HUMAN)search Homo sapienssearch 91% 348 89%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB

Chain Sequence family (Pfam)
A (Q02750) PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (Q02750) protein kinase activitysearch protein serine/threonine kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch