3zlw Summary details

pdbe.org/3zlw/summary_details
spacer Crystal structure of MEK1 in complex with fragment 3
Summary
Header TRANSFERASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.12 Å, R-factor: 19.8%, Free R-factor: 24.81%, Spacegroup: P 61 2 2
Released 22/05/2013, deposition: 04/02/2013, last revision: 29/05/2013
Authors Amaning, K.search; Lowinsky, M.search; Vallee, F.search; Steier, V.search; Marcireau, C.search; Ugolini, A.search; Delorme, C.search; McCort, G.search; Andouche, C.search; Vougier, S.search; Llopart, S.search; Halland, N.search; Rak, A.search
Primary citation The Use of Virtual Screening and Differential Scanning Fluorimetry for the Rapid Identification of Fragments Active Against Mek1.
BIOORG.MED.CHEM.LETT.search vol:23, pag:3620 (2013) [PubMed 23648182 ]search
Keywords TRANSFERASEsearch
EC 2.7.12.2 ExPASy BRENDA search (A)
Organism Homo sapiens(human) 9606search(A)
UniProt Q02750search (A)
Solvent A
Related entries 3zls, 3zlx, 3zly, 3zm4
Polymers
Chain Id Name Type UniProt Residues in sample sequence % of sample sequence observed
A DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 MAPK/ERK KINASE 1, MEK 1, MEK1 Protein Q02750 (MP2K1_HUMAN)search
348 89%
Heterogens
Chain Id Name Ligands
A (1R)-1-HYDROXY-1-METHYL-2,3,6,7-TETRAHYDRO-1H,5H-PYRIDO[3,2,1-IJ]QUINOLIN-5-ONE MT8 search
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