spacer Crystal structure of MEK1 in complex with fragment 3
Accession Q02750search
Keywords Serine/threonine-protein kinase, Phosphoprotein, Nucleotide-binding, 3D-structure, Alternative splicing, Complete proteome, ATP-binding, Disease mutation, Ectodermal dysplasia, Kinase, Reference proteome, Nucleus, Tyrosine-protein kinase, Transferase, Cytoskeleton, Acetylation, Direct protein sequencing, Mental retardation, Cytoplasm, Cardiomyopathy
Copyrighted by the UniProt Consortium, see
Polymers A
Enzyme nomenclature
EC number ExPASy BRENDA search
Polymers A
Name mitogen-activated protein kinase kinase
Comment This enzyme is a dual-specific protein kinase and requires mitogen-activated protein kinase kinase kinase (MAPKKK) for activation. It is required for activation of EC, mitogen-activated protein kinase. Phosphorylation of MEK1 by Raf involves phosphorylation of two serine residues. Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.