3zls Summary


Crystal structure of MEK1 in complex with fragment 6

The structure was published by Amaning, K., Lowinski, M., Vallee, F., et al., Llopart, S., Halland, N., and Rak, A., in 2013 in a paper entitled "The Use of Virtual Screening and Differential Scanning Fluorimetry for the Rapid Identification of Fragments Active Against Mek1." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1. This molecule has the UniProt identifier Q02750 (MP2K1_HUMAN)search. The sample contained 348 residues which is < 90% of the natural sequence. Out of 348 residues 313 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 Q02750 (37-383) (MP2K1_HUMAN)search Homo sapienssearch 91% 348 90%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB

Chain Sequence family (Pfam)
A (Q02750) PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (Q02750) protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch