3zln Summary details

pdbe.org/3zln/summary_details
spacer Crystal structure of Bcl-xL in complex with inhibitor (Compound 3).
Summary
Header APOPTOSISsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.288 Å, R-factor: 18.64%, Free R-factor: 24.65%, Spacegroup: P 41 21 2
Released 24/04/2013, deposition: 04/02/2013, last revision: 05/06/2013
Authors Czabotar, P.E.search; Lessene, G.L.search; Smith, B.J.search; Colman, P.M.search
Primary citation Structure-Guided Design of a Selective Bcl-Xl Inhibitor
NAT.CHEM.BIOL.search vol:9, pag:390 (2013) [PubMed 23603658 ]search
Keywords APOPTOSISsearch, INHIBITORsearch
Organism Homo sapiens(human) 9606search(A)
UniProt Q07817search (A)
Solvent A
Related entries 3zk6, 3zlo, 3zlr
Polymers
Chain Id Name Type UniProt Residues in sample sequence % of sample sequence observed
A BCL-2-LIKE PROTEIN 1 Protein Q07817 (B2CL1_HUMAN)search
181 79%
Heterogens
Chain Id Name Ligands
A 6-[(8E)-8-(1,3-BENZOTHIAZOL-2-YLHYDRAZINYLIDENE)-6,7-DIHYDRO-5H-NAPHTHALEN-2-YL]PYRIDINE-2-CARBOXYLIC ACID H0Y search
A SULFATE ION SO4 search
A 1,2-ETHANEDIOL EDO search
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