Crystal structure of Bcl-xL in complex with inhibitor (Compound 3).
The structure was published by Lessene, G.L., Czabotar, P.E., Sleebs, B.E., et al., Yang, H., Huang, D.C.S., and Watson, K.G., in 2013 in a paper entitled "Structure-Guided Design of a Selective Bcl-Xl Inhibitor" (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.288 Å and deposited in 2013.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of BCL-2-LIKE PROTEIN 1. This molecule has the UniProt identifier Q07817 (B2CL1_HUMAN). The sample contained 181 residues which is < 90% of the natural sequence. Out of 181 residues 142 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: