3zln Summary


Crystal structure of Bcl-xL in complex with inhibitor (Compound 3).

The structure was published by Lessene, G.L., Czabotar, P.E., Sleebs, B.E., et al., Yang, H., Huang, D.C.S., and Watson, K.G., in 2013 in a paper entitled "Structure-Guided Design of a Selective Bcl-Xl Inhibitor" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.288 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of BCL-2-LIKE PROTEIN 1. This molecule has the UniProt identifier Q07817 (B2CL1_HUMAN)search. The sample contained 181 residues which is < 90% of the natural sequence. Out of 181 residues 142 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A BCL-2-LIKE PROTEIN 1 Q07817 (1-209) (B2CL1_HUMAN)search Homo sapienssearch 90% 181 79%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q07817 (1 - 209) BCL-2-LIKE PROTEIN 1 Homo sapiens

Chain Sequence family (Pfam)
A (Q07817) PF00452: Apoptosis regulator proteins, Bcl-2 familysearch, PF02180: Bcl-2 homology region 4search

Chain ID Biological process (GO)
A (Q07817) regulation of apoptotic processsearch

Chain InterPro annotation
A Bcl2-likesearch Apoptosis regulator, Bcl-2 protein, BH4search Apoptosis regulator, Bcl-Xsearch Apoptosis regulator, Bcl-2, BH1 motif, conserved sitesearch Apoptosis regulator, Bcl-2, BH2 motif, conserved sitesearch Apoptosis regulator, Bcl-2, BH3 motif, conserved sitesearch Apoptosis regulator, Bcl-2, BH4 motif, conserved sitesearch Blc2 familysearch