3zhv Summary details

pdbe.org/3zhv/summary_details
spacer Crystal structure of the SucA domain of Mycobacterium smegmatis KGD, post-decarboxylation intermediate from pyruvate (2-hydroxyethyl-ThDP)
Summary
Header OXIDOREDUCTASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.3 Å, R-factor: 20.5%, Free R-factor: 23.54%, Spacegroup: P 1
Released 13/11/2013, deposition: 24/12/2012, last revision: 29/01/2014
Authors Wagner, T.search; Barilone, N.search; Bellinzoni, M.search; Alzari, P.M.search
Primary citation A Dual Conformation of the Post-Decarboxylation Intermediate is Associated with Distinct Enzyme States in Mycobacterial Alpha-Ketoglutarate Decarboxylase (Kgd).
BIOCHEM.J.search vol:457, pag:425 (2014) [PubMed 24171907 ]search
Keywords OXIDOREDUCTASEsearch, E1Osearch
EC 4.1.1.71 ExPASy BRENDA search (C D A B), 2.2.1.5 ExPASy BRENDA search (A C B D), 2.3.1.61 ExPASy BRENDA search 1.2.4.2 ExPASy BRENDA search (C B A D)
Organism Mycobacterium smegmatis 1772search(A B C D)
UniProt A0R2B1search (A B C D)
Solvent A, B, C, D
Related entries 3zhq, 3zhr, 3zhs, 3zht, 3zhu
Polymers
Chain Id Name Type UniProt Residues in sample sequence % of sample sequence observed
A, B, C, D MULTIFUNCTIONAL 2-OXOGLUTARATE METABOLISM ENZYME Protein A0R2B1 (KGD_MYCS2)search
868 94%
Heterogens
Chain Id Name Ligands
A, B, C, D 2-[3-[(4-AZANYL-2-METHYL-PYRIMIDIN-5-YL)METHYL]-4-METHYL-2-[(1S)-1-OXIDANYLETHYL]-1,3-THIAZOL-3-IUM-5-YL]ETHYL PHOSPHONO HYDROGEN PHOSPHATE TDW search
A, B, C, D MAGNESIUM ION MG search
A, B, C, D CALCIUM ION CA search
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