3zhv Summary

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Crystal structure of the SucA domain of Mycobacterium smegmatis KGD, post-decarboxylation intermediate from pyruvate (2-hydroxyethyl-ThDP)

The structure was published by Wagner, T., Barilone, N., Alzari, P.M., and Bellinzoni, M., in 2014 in a paper entitled "A Dual Conformation of the Post-Decarboxylation Intermediate is Associated with Distinct Enzyme States in Mycobacterial Alpha-Ketoglutarate Decarboxylase (Kgd)." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of MULTIFUNCTIONAL 2-OXOGLUTARATE METABOLISM ENZYME.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MULTIFUNCTIONAL 2-OXOGLUTARATE METABOLISM ENZYME A0R2B1 (361-1227) (KGD_MYCS2)search Mycobacterium smegmatis str. MC2 155search 91% 868 94%
B MULTIFUNCTIONAL 2-OXOGLUTARATE METABOLISM ENZYME A0R2B1 (361-1227) (KGD_MYCS2)search Mycobacterium smegmatis str. MC2 155search 91% 868 94%
C MULTIFUNCTIONAL 2-OXOGLUTARATE METABOLISM ENZYME A0R2B1 (361-1227) (KGD_MYCS2)search Mycobacterium smegmatis str. MC2 155search 91% 868 94%
D MULTIFUNCTIONAL 2-OXOGLUTARATE METABOLISM ENZYME A0R2B1 (361-1227) (KGD_MYCS2)search Mycobacterium smegmatis str. MC2 155search 91% 868 94%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
A0R2B1 (361 - 1227) MULTIFUNCTIONAL 2-OXOGLUTARATE METABOLISM ENZYME Mycobacterium smegmatis

Chain Sequence family (Pfam)
A, B, C, D (A0R2B1) PF00676: Dehydrogenase E1 componentsearch, PF02779: Transketolase, pyrimidine binding domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B, C, D (A0R2B1) thiamine pyrophosphate bindingsearch oxoglutarate dehydrogenase (succinyl-transferring) activitysearch oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptorsearch oxidation-reduction processsearch metabolic processsearch tricarboxylic acid cyclesearch

Chain InterPro annotation
A, B, C, D Dehydrogenase, E1 componentsearch Transketolase-like, pyrimidine-binding domainsearch 2-oxoglutarate dehydrogenase E1 componentsearch Thiamin diphosphate-binding foldsearch