› 3zgq

X-ray diffraction
2.2Å resolution

Crystal structure of human interferon-induced protein IFIT5

Released:
DOI: 10.2210/pdb3zgq/pdb
PDB entry 3zgq coloured by chain, front view.
PDB entry 3zgq coloured by chain, side view.
PDB entry 3zgq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
tRNA binding, structure, and localization of the human interferon-induced protein IFIT5.
Katibah GE, Lee HJ, Huizar JP, Vogan JM, Alber T, Collins K
Mol Cell 49 743-50 (2013)
PMID: 23317505

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171638 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interferon-induced protein with tetratricopeptide repeats 5 Chain: A
Molecule details ›
Chain: A
Length: 482 amino acids
Theoretical weight: 55.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13325 (Residues: 1-482; Coverage: 100%)
Gene names: IFIT5, ISG58, RI58
Sequence domains:
Structure domains: Tetratricopeptide repeat domain

Ligands and Environments

1 bound ligand:
Ligand PEG 1 x PEG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P212121
Unit cell:
a: 63.833Å b: 71.793Å c: 116.92Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.178 0.24
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

15 review citations

Transfer RNA and human disease.
Abbott et al. (2014)
14 more

4 mentions without citation

Broad and adaptable RNA structure recognition by the human interferon-induced tetratricopeptide repeat protein IFIT5.
Katibah et al. (2014)
3 more