› 3zdu

X-ray diffraction
2.2Å resolution

Crystal structure of the human CDKL3 kinase domain

Released:
DOI: 10.2210/pdb3zdu/pdb
PDB entry 3zdu coloured by chain, front view.
PDB entry 3zdu coloured by chain, side view.
PDB entry 3zdu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function.
Canning P, Park K, Gonçalves J, Li C, Howard CJ, Sharpe TD, Holt LJ, Pelletier L, Bullock AN, Leroux MR
Cell Rep 22 885-894 (2018)
PMID: 29420175

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184881 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclin-dependent kinase-like 3 Chain: A
Molecule details ›
Chain: A
Length: 325 amino acids
Theoretical weight: 37.35 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8IVW4 (Residues: 1-324; Coverage: 55%)
Gene names: CDKL3, NKIAMRE
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand 38R 1 x 38R
Ligand ZN 2 x ZN
Ligand NA 1 x NA
Ligand EDO 2 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P3121
Unit cell:
a: 63.93Å b: 63.93Å c: 163.63Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.217 0.214 0.262
Expression system: Spodoptera frugiperda

Quick links

Citations

11 review citations

Cilia Distal Domain: Diversity in Evolutionarily Conserved Structures.
Soares et al. (2019)
10 more

4 mentions without citation

Structure of LRRK2 in Parkinson's disease and model for microtubule interaction.
Deniston et al. (2020)
3 more