› 3zdq

X-ray diffraction
2.85Å resolution

STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10 (NUCLEOTIDE-FREE FORM)

Released:
DOI: 10.2210/pdb3zdq/pdb
PDB entry 3zdq coloured by chain, front view.
PDB entry 3zdq coloured by chain, side view.
PDB entry 3zdq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states.
Shintre CA, Pike AC, Li Q, Kim JI, Barr AJ, Goubin S, Shrestha L, Yang J, Berridge G, Ross J, Stansfeld PJ, Sansom MS, Edwards AM, Bountra C, Marsden BD, von Delft F, Bullock AN, Gileadi O, Burgess-Brown NA, Carpenter EP
Proc Natl Acad Sci U S A 110 9710-5 (2013)
PMID: 23716676

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192563 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ATP-binding cassette sub-family B member 10, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 595 amino acids
Theoretical weight: 64.82 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9NRK6 (Residues: 152-738; Coverage: 80%)
Gene name: ABCB10
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand GLY 1 x GLY
Ligand LMT 3 x LMT
Ligand CDL 2 x CDL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P3121
Unit cell:
a: 177.79Å b: 177.79Å c: 50.06Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.204 0.202 0.244
Expression system: Spodoptera frugiperda

Quick links

Citations

28 review citations

Secretion systems in Gram-negative bacteria: structural and mechanistic insights.
Costa et al. (2015)
27 more

19 mentions without citation

Structural diversity of ABC transporters.
ter Beek et al. (2014)
18 more