› 3zbl

X-ray diffraction
1.9Å resolution

Function and Biology Details

Reaction catalysed: 
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3-alpha,7-alpha,12-alpha-trihydroxy-24-oxo-5-beta-cholestanoyl-CoA
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-123156 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
propanoyl-CoA C-acyltransferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 457 amino acids
Theoretical weight: 49.24 KDa
Source organism: Leishmania mexicana
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: E9AW84 (Residues: 1-441; Coverage: 100%)
Gene name: LMXM_23_0690
Sequence domains:
Structure domains: Peroxisomal Thiolase; Chain A, domain 1

Ligands and Environments

3 bound ligands:
Ligand CL 2 x CL
Ligand DMS 15 x DMS
Ligand MPD 4 x MPD
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P65
Unit cell:
a: 123.274Å b: 123.274Å c: 133.012Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.191 0.189 0.222
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Acquisition and biosynthesis of saturated and unsaturated fatty acids by trypanosomatids.
Uttaro AD. (2014)
2 more