› 3zbg

X-ray diffraction
1.85Å resolution

Function and Biology Details

Reaction catalysed: 
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3-alpha,7-alpha,12-alpha-trihydroxy-24-oxo-5-beta-cholestanoyl-CoA
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-123156 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
propanoyl-CoA C-acyltransferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 457 amino acids
Theoretical weight: 49.31 KDa
Source organism: Leishmania mexicana
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: E9AW84 (Residues: 1-441; Coverage: 100%)
Gene name: LMXM_23_0690
Sequence domains:
Structure domains: Peroxisomal Thiolase; Chain A, domain 1

Ligands and Environments

2 bound ligands:
Ligand DMS 14 x DMS
Ligand MPD 4 x MPD
1 modified residue:
Ligand OCS 2 x OCS

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P65
Unit cell:
a: 122.249Å b: 122.249Å c: 133.081Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.164 0.162 0.196
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Acquisition and biosynthesis of saturated and unsaturated fatty acids by trypanosomatids.
Uttaro AD. (2014)
1 more

5 mentions without citation

The Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking Investigations.
Ogungbe et al. (2016)
4 more