› 3whd

X-ray diffraction
2.29Å resolution

C-type lectin, human MCL

Released:
DOI: 10.2210/pdb3whd/pdb
PDB entry 3whd coloured by chain, front view.
PDB entry 3whd coloured by chain, side view.
PDB entry 3whd coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural analysis for glycolipid recognition by the C-type lectins Mincle and MCL.
Furukawa A, Kamishikiryo J, Mori D, Toyonaga K, Okabe Y, Toji A, Kanda R, Miyake Y, Ose T, Yamasaki S, Maenaka K
Proc Natl Acad Sci U S A 110 17438-43 (2013)
PMID: 24101491

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-186788 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-type lectin domain family 4 member D Chains: A, C
Molecule details ›
Chains: A, C
Length: 156 amino acids
Theoretical weight: 18.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8WXI8 (Residues: 61-215; Coverage: 72%)
Gene names: CLEC4D, CLECSF8, MCL
Sequence domains: Lectin C-type domain
Structure domains: Mannose-Binding Protein A, subunit A

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL32XU
Spacegroup: I222
Unit cell:
a: 85.19Å b: 96.056Å c: 104.826Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.176 0.218
Expression system: Escherichia coli

Quick links

Citations

21 review citations

Recent insights into structures and functions of C-type lectins in the immune system.
Drickamer et al. (2015)
20 more

5 mentions without citation

MCL and Mincle: C-Type Lectin Receptors That Sense Damaged Self and Pathogen-Associated Molecular Patterns.
Richardson et al. (2014)
4 more