3wd5 Summary

pdbe.org/3wd5
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Crystal structure of TNFalpha in complex with Adalimumab Fab fragment

The structure was published by Hu, S., Liang, S.Y., Guo, H., et al., Wang, H., Guo, Y.J., and Lou, Z.Y., in 2013 in a paper entitled "Comparison of the inhibition mechanisms of Adalimumab and Infliximab in treating TNFalpha-associated diseases from a molecular view" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.101 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely Tumor necrosis factor, Adalimumab Light Chain, and Adalimumab Heavy Chain.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Tumor necrosis factor P01375 (77-233) (TNFA_HUMAN)search Homo sapienssearch < 90% 157 96%
L Adalimumab Light Chain Not available
Homo sapienssearch Not available 213 100%
H Adalimumab Heavy Chain Not available
Homo sapienssearch Not available 219 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P01375 (77 - 233) Tumor necrosis factor Homo sapiens

Chain Sequence family (Pfam)
A TNF(Tumour Necrosis Factor) familysearch
L
H

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P01375) tumor necrosis factor receptor bindingsearch immune responsesearch membranesearch

Chain InterPro annotation
A Tumour necrosis factor alphasearch Tumour necrosis factor domainsearch Tumour necrosis factorsearch Tumour necrosis factor-like domainsearch Tumour necrosis factor, conserved sitesearch
L Immunoglobulin/major histocompatibility complex, conserved sitesearch search Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch
H search Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch