3w13 Summary

pdbe.org/3w13
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Insulin receptor ectodomain construct comprising domains L1-CR in complex with high-affinity insulin analogue [D-PRO-B26]-DTI-NH2, alphact peptide(693-719) and FAB 83-7

There is a Quite Interesting Protein Structure article for this entry.

The structure was published by Menting, J.G., Whittaker, J., Margetts, M.B., et al., Weiss, M.A., Ward, C.W., and Lawrence, M.C., in 2013 in a paper entitled "How insulin engages its primary binding site on the insulin receptor" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 4.303 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This entry contains 10 copies of 6 unique biopolymers (complete list).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterohexamers.


The are more than 5 unique protein polymers in this entry. More information is available on the Uniprot cross references page.

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P06213 (28 - 337) Insulin receptor domains L1-CR Homo sapiens
P01308 (90 - 110) Insulin A chain HOMO SAPIENS

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