3vt8 Summary details

pdbe.org/3vt8/summary_details
spacer Crystal structures of rat VDR-LBD with W282R mutation
Summary
Header HORMONE RECEPTORsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.1 Å, R-factor: 18.9%, Free R-factor: 23.5%, Spacegroup: C 1 2 1
Released 22/05/2013, deposition: 19/05/2012, last revision: 12/02/2014
Authors Nakabayashi, M.search; Shimizu, M.search; Ikura, T.search; Ito, N.search
Primary citation Crystal structures of hereditary vitamin D-resistant rickets-associated vitamin D receptor mutants R270L and W282R bound to 1,25-dihydroxyvitamin D3 and synthetic ligands.
J.MED.CHEM.search vol:56, pag:6745-6760 (2013) [PubMed 23944708 ]search
Keywords Transcriptionsearch, HORMONE RECEPTORsearch
Organism Rattus norvegicus(Norway rat) 10116search(A)
UniProt P13053search (A)
Solvent A, C
Related entries 2zlc, 3vt3, 3vt4, 3vt5, 3vt6, 3vt7, 3vt9
Polymers
Chain Id Name Type UniProt Residues in sample sequence % of sample sequence observed
A Vitamin D3 receptor Protein P13053 (VDR_RAT)search
271 85%
C COACTIVATOR PEPTIDE DRIP Protein
13 84%
Heterogens
Chain Id Name Ligands
A (1R,3R,7E,9BETA,17BETA)-9-BUTYL-17-[(2R)-6-HYDROXY-6-METHYLHEPTAN-2-YL]-9,10-SECOESTRA-5,7-DIENE-1,3-DIOL YI3 search
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