3vt6 Summary

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Crystal structure of rat VDR-LBD with 2-Substituted-16-ene-22-thia-1alpha,25-dihydroxy-26,27-dimethyl-19-norvitamin D3

The structure was published by Nakabayashi, M., Tsukahara, Y., Iwasaki-Miyamoto, Y., et al., Tokiwa, H., Ikura, T., and Ito, N., in 2013 in a paper entitled "Crystal structures of hereditary vitamin D-resistant rickets-associated vitamin D receptor mutants R270L and W282R bound to 1,25-dihydroxyvitamin D3 and synthetic ligands." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Vitamin D3 receptor and COACTIVATOR PEPTIDE DRIP.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Vitamin D3 receptor P13053 (116-423) (VDR_RAT)search Rattus norvegicussearch < 90% 271 88%
C COACTIVATOR PEPTIDE DRIP Not available
Synthetic Not available 13 84%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P13053 (116 - 423) Vitamin D3 receptor Rattus norvegicus

Chain Sequence family (Pfam)
A Ligand-binding domain of nuclear hormone receptorsearch
C

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P13053) regulation of transcription, DNA-dependentsearch steroid hormone mediated signaling pathwaysearch nucleussearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch steroid hormone receptor activitysearch thyroid hormone receptor activitysearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Thyroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch
C