3vt4 Summary


Crystal structures of rat VDR-LBD with R270L mutation

The structure was published by Nakabayashi, M., Tsukahara, Y., Iwasaki-Miyamoto, Y., et al., Tokiwa, H., Ikura, T., and Ito, N., in 2013 in a paper entitled "Crystal structures of hereditary vitamin D-resistant rickets-associated vitamin D receptor mutants R270L and W282R bound to 1,25-dihydroxyvitamin D3 and synthetic ligands." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Vitamin D3 receptor and COACTIVATOR PEPTIDE DRIP.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Vitamin D3 receptor P13053 (116-269) (VDR_RAT)search ,
P13053 (271-423) (VDR_RAT)search
Rattus norvegicussearch ,
Rattus norvegicussearch
< 90% ,
< 90%
271 88%
Synthetic Not available 13 84%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P13053 (116 - 269) Vitamin D3 receptor Rattus norvegicus

Chain Sequence family (Pfam)
A Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P13053) thyroid hormone receptor activitysearch DNA bindingsearch steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch nucleussearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Thyroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch