3vf0 Summary


Raver1 in complex with metavinculin L954 deletion mutant

The structure was published by Lee, J.H., Rangarajan, E.S., Vonrhein, C., Bricogne, G., and Izard, T., in 2012 in a paper entitled "The Metavinculin Tail Domain Directs Constitutive Interactions with Raver1 and vinculin RNA." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.54 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Vinculin and Ribonucleoprotein PTB-binding 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Vinculin P18206 (856-1134) (VINC_HUMAN)search Homo sapienssearch 94% 283 62%
B Ribonucleoprotein PTB-binding 1 Q8IY67 (39-321) (RAVR1_HUMAN)search Homo sapienssearch < 90% 285 99%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P18206 (856 - 1134) Vinculin Homo sapiens
Q8IY67 (39 - 321) Ribonucleoprotein PTB-binding 1 Homo sapiens

Chain Sequence family (Pfam)
A (P18206) PF01044: Vinculin familysearch
B RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)search, RNA recognition motif (a.k.a. RRM, RBD, or RNP domain)search

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P18206) cell adhesionsearch structural molecule activitysearch actin cytoskeletonsearch
B (Q8IY67) nucleic acid bindingsearch nucleotide bindingsearch

Chain InterPro annotation
A Vinculin/alpha-cateninsearch Vinculinsearch
B RNA recognition motif domainsearch Nucleotide-binding alpha-beta plait domainsearch