3vev Summary


Glucokinase in complex with an activator and glucose

The structure was published by Liu, S., Ammirati, M.J., Song, X., et al., Greasley, S.E., Pfefferkorn, J.A., and Qiu, X., in 2012 in a paper entitled "Insights into Mechanism of Glucokinase Activation: OBSERVATION OF MULTIPLE DISTINCT PROTEIN CONFORMATIONS." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Glucokinase. This molecule has the UniProt identifier P35557 (HXK4_HUMAN)search. The sample contained 470 residues which is 98% of the natural sequence. Out of 470 residues 448 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glucokinase P35557 (12-465) (HXK4_HUMAN)search Homo sapienssearch 97% 470 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35557 (12 - 465) Glucokinase Homo sapiens

Chain Sequence family (Pfam)
A (P35557) PF00349: Hexokinasesearch, PF03727: Hexokinasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P35557) carbohydrate metabolic processsearch cellular response to leptin stimulussearch hexose transportsearch transmembrane transportsearch second-messenger-mediated signalingsearch regulation of insulin secretionsearch positive regulation of insulin secretionsearch cellular response to insulin stimulussearch glucose homeostasissearch glucose metabolic processsearch glycolytic processsearch regulation of glycolytic processsearch carbohydrate phosphorylationsearch positive regulation of glycolytic processsearch positive regulation of phosphorylationsearch cellular response to glucose starvationsearch small molecule metabolic processsearch glucose transportsearch cellular glucose homeostasissearch glycogen biosynthetic processsearch negative regulation of epinephrine secretionsearch glucose 6-phosphate metabolic processsearch endocrine pancreas developmentsearch detection of glucosesearch calcium ion importsearch regulation of potassium ion transportsearch NADP metabolic processsearch regulation of glucose transportsearch negative regulation of gluconeogenesissearch positive regulation of glycogen biosynthetic processsearch metabolic processsearch positive regulation of cytosolic calcium ion concentrationsearch phosphorylationsearch response to glucosesearch fructose 2,6-bisphosphate metabolic processsearch ATP bindingsearch glucokinase activitysearch glucose bindingsearch phosphotransferase activity, alcohol group as acceptorsearch hexokinase activitysearch catalytic activitysearch kinase activitysearch mannokinase activitysearch magnesium ion bindingsearch protein phosphatase bindingsearch protein bindingsearch fructokinase activitysearch transferase activitysearch nucleotide bindingsearch ADP bindingsearch cytoplasmsearch cytosolsearch mitochondrionsearch nucleoplasmsearch secretory granulesearch nucleussearch cell cortexsearch

Chain InterPro annotation
A Hexokinasesearch Hexokinase, conserved sitesearch Hexokinase, N-terminalsearch Hexokinase, C-terminalsearch