› 3vas

X-ray diffraction
2.26Å resolution

Adenosine kinase from Schistosoma mansoni in complex with adenosine in occluded loop conformation

Released:
DOI: 10.2210/pdb3vas/pdb
PDB entry 3vas coloured by chain, front view.
PDB entry 3vas coloured by chain, side view.
PDB entry 3vas coloured by chain, top view.
Source organism: Schistosoma mansoni
Primary publication:
Adenosine kinase from Schistosoma mansoni: structural basis for the differential incorporation of nucleoside analogues.
Romanello L, Bachega JF, Cassago A, Brandão-Neto J, DeMarco R, Garratt RC, Pereira HD
Acta Crystallogr D Biol Crystallogr 69 126-36 (2013)
PMID: 23275171

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-164165 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Putative adenosine kinase Chains: A, B
Molecule details ›
Chains: A, B
Length: 370 amino acids
Theoretical weight: 41.34 KDa
Source organism: Schistosoma mansoni
Expression system: Escherichia coli BL21(DE3)
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand ADN 2 x ADN
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P21212
Unit cell:
a: 58.97Å b: 180.12Å c: 79.27Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.179 0.177 0.222
Expression system: Escherichia coli BL21(DE3)

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Citations

2 review citations

Purinergic signaling in schistosomal infection.
Silva CLM. (2016)
1 more