3v7a Summary

pdbe.org/3v7a
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Structural basis for broad detection of genogroup II noroviruses by a monoclonal antibody that binds to a site occluded in the viral particle

The structure was published by Hansman, G.S., Taylor, D.W., McLellan, J.S., et al., Katayama, K., Murata, K., and Kwong, P.D., in 2012 in a paper entitled "Structural Basis for Broad Detection of Genogroup II Noroviruses by a Monoclonal Antibody That Binds to a Site Occluded in the Viral Particle." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.297 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely 5B18 heavy chain, 5B18 kappa chain, and Capsid.

The molecule most likely forms heterohexamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
F 5B18 heavy chain Not available
Mus musculussearch Not available 223 98%
E 5B18 heavy chain Not available
Mus musculussearch Not available 223 98%
G 5B18 kappa chain Not available
Mus musculussearch Not available 215 100%
H 5B18 kappa chain Not available
Mus musculussearch Not available 215 100%
A Capsid Q5F4T5 (224-538) (Q5F4T5_9CALI)search Norwalk virussearch < 90% 315 100%
B Capsid Q5F4T5 (224-538) (Q5F4T5_9CALI)search Norwalk virussearch < 90% 315 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q5F4T5 (224 - 538) Capsid Norovirus isolates

Chain Structural classification (CATH) Sequence family (Pfam)
F, E Immunoglobulinssearch
G, H Immunoglobulinssearch
A, B Positive stranded ssRNA virusessearch Calicivirus coat proteinsearch, Calicivirus coat protein C-terminalsearch
Chain InterPro annotation
F, E search Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch
G, H Immunoglobulin/major histocompatibility complex, conserved sitesearch search Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch
A, B Calicivirus coat protein/non-structural polyproteinsearch Calicivirus coat protein C-terminalsearch