3v5g Summary


Crystal structure of human carbonic anhydrase II in complex with the 4-sulfamido-benzenesulfonamide inhibitor

The structure was published by D'Ambrosio, K., Smaine, F.Z., Carta, F., De Simone, G., Winum, J.Y., and Supuran, C.T., in 2012 in a paper entitled "Development of potent carbonic anhydrase inhibitors incorporating both sulfonamide and sulfamide groups." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.5 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Sequence family (Pfam)
A (P00918) PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P00918) one-carbon metabolic processsearch regulation of intracellular pHsearch morphogenesis of an epitheliumsearch positive regulation of dipeptide transmembrane transportsearch response to pHsearch small molecule metabolic processsearch bicarbonate transportsearch regulation of chloride transportsearch positive regulation of synaptic transmission, GABAergicsearch positive regulation of cellular pH reductionsearch positive regulation of osteoclast differentiationsearch secretionsearch angiotensin-activated signaling pathwaysearch regulation of anion transportsearch positive regulation of bone resorptionsearch response to zinc ionsearch kidney developmentsearch response to estrogensearch response to steroid hormonesearch response to organic substancesearch odontogenesis of dentin-containing toothsearch zinc ion bindingsearch carbonate dehydratase activitysearch protein bindingsearch metal ion bindingsearch lyase activitysearch cytosolsearch basolateral plasma membranesearch cytoplasmsearch myelin sheathsearch apical part of cellsearch plasma membranesearch extracellular vesicular exosomesearch microvillussearch membranesearch extracellular spacesearch axonsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch