› 3v42

X-ray diffraction
2Å resolution

Crystal structure of renal tumor suppressor protein, folliculin

Released:
DOI: 10.2210/pdb3v42/pdb
PDB entry 3v42 coloured by chain, front view.
PDB entry 3v42 coloured by chain, side view.
PDB entry 3v42 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer.
Nookala RK, Langemeyer L, Pacitto A, Ochoa-Montaño B, Donaldson JC, Blaszczyk BK, Chirgadze DY, Barr FA, Bazan JF, Blundell TL
Open Biol 2 120071 (2012)
PMID: 22977732

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-185526 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Folliculin Chains: A, B
Molecule details ›
Chains: A, B
Length: 226 amino acids
Theoretical weight: 25.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8NFG4 (Residues: 341-566; Coverage: 39%)
Gene names: BHD, FLCN
Sequence domains: Folliculin C-terminal domain
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: C2221
Unit cell:
a: 86.05Å b: 99.951Å c: 107.584Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.204 0.268
Expression system: Escherichia coli

Quick links

Citations

18 review citations

Molecular genetics and clinical features of Birt-Hogg-Dubé syndrome.
Schmidt et al. (2015)
17 more

12 mentions without citation

FLCN: The causative gene for Birt-Hogg-Dubé syndrome.
Schmidt et al. (2018)
11 more