3v3h Summary

pdbe.org/3v3h
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Kinetic and structural studies of thermostabilized mutants of HCA II.

The structure was published by Fisher, Z., Boone, C.D., Biswas, S.M., et al., Agbandje-McKenna, M., Silverman, D., and McKenna, R., in 2012 in a paper entitled "Kinetic and structural characterization of thermostabilized mutants of human carbonic anhydrase II." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.85 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
B Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Sequence family (Pfam)
B (P00918) PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
B (P00918) positive regulation of cellular pH reductionsearch response to organic substancesearch bicarbonate transportsearch small molecule metabolic processsearch positive regulation of dipeptide transmembrane transportsearch regulation of intracellular pHsearch positive regulation of bone resorptionsearch angiotensin-activated signaling pathwaysearch odontogenesis of dentin-containing toothsearch morphogenesis of an epitheliumsearch response to estrogensearch carbon dioxide transportsearch kidney developmentsearch response to pHsearch positive regulation of osteoclast differentiationsearch response to zinc ionsearch regulation of anion transportsearch secretionsearch response to steroid hormonesearch carbonate dehydratase activitysearch metal ion bindingsearch zinc ion bindingsearch lyase activitysearch protein bindingsearch microvillussearch cytoplasmsearch cytosolsearch plasma membranesearch apical part of cellsearch axonsearch extracellular vesicular exosomesearch membranesearch basolateral plasma membranesearch extracellular spacesearch

Chain InterPro annotation
B Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch