3v2y Summary

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Crystal Structure of a Lipid G protein-Coupled Receptor at 2.80A

The structure was published by Hanson, M.A., Roth, C.B., Jo, E., et al., Kuhn, P., Rosen, H., and Stevens, R.C., in 2012 in a paper entitled "Crystal structure of a lipid G protein-coupled receptor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Sphingosine 1-phosphate receptor 1, Lysozyme chimera. This molecule has the UniProt identifier P21453 (S1PR1_HUMAN)search. The sample contained 520 residues which is 98% of the natural sequence. Out of 520 residues 439 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Sphingosine 1-phosphate receptor 1, Lysozyme chimera P00720 (2-161) (LYS_BPT4)search ,
P21453 (2-231) (S1PR1_HUMAN)search ,
P21453 (244-325) (S1PR1_HUMAN)search
Enterobacteria phage T4search ,
Homo sapienssearch ,
Homo sapienssearch
93% ,
< 90% ,
< 90%
520 87%


Chain Sequence family (Pfam)
A (P00720) PF00959: Phage lysozymesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P21453P00720) lysozyme activitysearch catalytic activitysearch hydrolase activity, acting on glycosyl bondssearch hydrolase activitysearch G-protein coupled receptor activitysearch peptidoglycan catabolic processsearch cell wall macromolecule catabolic processsearch defense response to bacteriumsearch metabolic processsearch cytolysissearch G-protein coupled receptor signaling pathwaysearch integral to membranesearch

Chain InterPro annotation
A G protein-coupled receptor, rhodopsin-likesearch Bacteriophage T4, Gp5, tail-associated lysozymesearch Glycoside hydrolase, family 24search GPCR, rhodopsin-like, 7TMsearch Lysozyme-like domainsearch Lysozyme domainsearch