3v2y Summary


Crystal Structure of a Lipid G protein-Coupled Receptor at 2.80A

The structure was published by Hanson, M.A., Roth, C.B., Jo, E., et al., Kuhn, P., Rosen, H., and Stevens, R.C., in 2012 in a paper entitled "Crystal structure of a lipid G protein-coupled receptor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Sphingosine 1-phosphate receptor 1, Lysozyme chimera. This molecule has the UniProt identifier P21453 (S1PR1_HUMAN)search. The sample contained 520 residues which is 98% of the natural sequence. Out of 520 residues 439 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Sphingosine 1-phosphate receptor 1, Lysozyme chimera P00720 (2-161) (ENLYS_BPT4)search ,
P21453 (2-231) (S1PR1_HUMAN)search ,
P21453 (244-325) (S1PR1_HUMAN)search
Enterobacteria phage T4search ,
Homo sapienssearch ,
Homo sapienssearch
93% ,
< 90% ,
< 90%
520 87%

Chain Sequence family (Pfam)
A (P00720) PF00959: Phage lysozymesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P21453P00720) lysozyme activitysearch catalytic activitysearch G-protein coupled receptor activitysearch hydrolase activitysearch hydrolase activity, acting on glycosyl bondssearch G-protein coupled receptor signaling pathwaysearch metabolic processsearch peptidoglycan catabolic processsearch cell wall macromolecule catabolic processsearch viral release from host cellsearch cytolysissearch defense response to bacteriumsearch integral component of membranesearch host cell cytoplasmsearch

Chain InterPro annotation
A G protein-coupled receptor, rhodopsin-likesearch Bacteriophage T4, Gp5, tail-associated lysozymesearch Glycoside hydrolase, family 24search GPCR, rhodopsin-like, 7TMsearch Lysozyme-like domainsearch Lysozyme domainsearch