3v2m Summary


Effect of Sucrose and Glycerol as Cryoprotectans, on the Inhibition of Human Carbonic Anhydrase II

A publication describing this structure is not available. The depositing authors are Aggarwal, M.search; McKenna, A.search

This crystal structure was determined using X-ray diffraction at a resolution of 1.471 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Sequence family (Pfam)
A (P00918) PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P00918) response to organic substancesearch regulation of intracellular pHsearch angiotensin-activated signaling pathwaysearch response to zinc ionsearch bicarbonate transportsearch kidney developmentsearch one-carbon metabolic processsearch positive regulation of dipeptide transmembrane transportsearch regulation of anion transportsearch positive regulation of cellular pH reductionsearch response to steroid hormonesearch positive regulation of osteoclast differentiationsearch secretionsearch morphogenesis of an epitheliumsearch response to estrogensearch positive regulation of bone resorptionsearch odontogenesis of dentin-containing toothsearch response to pHsearch small molecule metabolic processsearch regulation of chloride transportsearch positive regulation of synaptic transmission, GABAergicsearch plasma membranesearch extracellular vesicular exosomesearch cytosolsearch microvillussearch basolateral plasma membranesearch cytoplasmsearch axonsearch apical part of cellsearch extracellular spacesearch myelin sheathsearch membranesearch metal ion bindingsearch zinc ion bindingsearch protein bindingsearch carbonate dehydratase activitysearch lyase activitysearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch