3v2j Summary


Effect of Sucrose and Glycerol as Cryoprotectans, on the Inhibition of Human Carbonic Anhydrase II

A publication describing this structure is not available. The depositing authors are Aggarwal, M.search; McKenna, A.search

This crystal structure was determined using X-ray diffraction at a resolution of 1.699 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P00918) odontogenesis of dentin-containing toothsearch small molecule metabolic processsearch kidney developmentsearch regulation of chloride transportsearch positive regulation of dipeptide transmembrane transportsearch bicarbonate transportsearch response to estrogensearch cellular response to fluid shear stresssearch secretionsearch regulation of intracellular pHsearch positive regulation of bone resorptionsearch positive regulation of cellular pH reductionsearch positive regulation of osteoclast differentiationsearch response to zinc ionsearch morphogenesis of an epitheliumsearch positive regulation of synaptic transmission, GABAergicsearch regulation of anion transportsearch response to steroid hormonesearch response to pHsearch angiotensin-activated signaling pathwaysearch response to organic substancesearch one-carbon metabolic processsearch lyase activitysearch protein bindingsearch carbonate dehydratase activitysearch metal ion bindingsearch zinc ion bindingsearch cytosolsearch membranesearch cytoplasmsearch plasma membranesearch microvillussearch extracellular spacesearch basolateral plasma membranesearch myelin sheathsearch extracellular vesicular exosomesearch apical part of cellsearch axonsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch