3ug9 Summary


Crystal Structure of the Closed State of Channelrhodopsin

The structure was published by Kato, H.E., Zhang, F., Yizhar, O., et al., Ishitani, R., Deisseroth, K., and Nureki, O., in 2012 in a paper entitled "Crystal structure of the channelrhodopsin light-gated cation channel" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Archaeal-type opsin 1, Archaeal-type opsin 2. This molecule has the UniProt identifier Q93WP2 (Q93WP2_CHLRE)search. The sample contained 333 residues which is < 90% of the natural sequence. Out of 333 residues 273 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Archaeal-type opsin 1, Archaeal-type opsin 2 Q8RUT8 (207-309) (Q8RUT8_CHLRE)search ,
Q93WP2 (24-245) (Q93WP2_CHLRE)search
Chlamydomonas reinhardtiisearch ,
Chlamydomonas reinhardtiisearch
< 90% ,
< 90%
333 84%

Chain Sequence family (Pfam)
A Bacteriorhodopsin-like proteinsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (Q93WP2Q8RUT8) membranesearch ion channel activitysearch ion transportsearch

Chain InterPro annotation
A Archaeal/bacterial/fungal rhodopsinsearch Archaeal/bacterial/fungal rhodopsin-likesearch