3u47 Summary


Human Carbonic Anhydrase II V143L

A publication describing this structure is not available. The depositing authors are West, D.search; Mckenna, R.search

This crystal structure was determined using X-ray diffraction at a resolution of 1.6 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Sequence family (Pfam)
A (P00918) PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00918) carbonate dehydratase activitysearch protein bindingsearch lyase activitysearch metal ion bindingsearch zinc ion bindingsearch one-carbon metabolic processsearch positive regulation of bone resorptionsearch positive regulation of dipeptide transmembrane transportsearch bicarbonate transportsearch odontogenesis of dentin-containing toothsearch response to steroid hormonesearch response to estrogensearch response to pHsearch response to organic substancesearch angiotensin-activated signaling pathwaysearch regulation of intracellular pHsearch morphogenesis of an epitheliumsearch positive regulation of cellular pH reductionsearch secretionsearch regulation of anion transportsearch carbon dioxide transportsearch small molecule metabolic processsearch positive regulation of osteoclast differentiationsearch response to zinc ionsearch kidney developmentsearch cytoplasmsearch apical part of cellsearch plasma membranesearch cytosolsearch axonsearch extracellular vesicular exosomesearch extracellular spacesearch microvillussearch basolateral plasma membranesearch membranesearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch