3tzi Summary

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X-ray crystal structure of arachidonic acid bound in the cyclooxygenase channel of G533V murine COX-2

The structure was published by Vecchio, A.J., Orlando, B.J., Nandagiri, R., and Malkowski, M.G., in 2012 in a paper entitled "Investigating Substrate Promiscuity in Cyclooxygenase-2: THE ROLE OF ARG-120 AND RESIDUES LINING THE HYDROPHOBIC GROOVE." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.15 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Prostaglandin G/H synthase 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Prostaglandin G/H synthase 2 Q05769 (20-604) (PGH2_MOUSE)search Mus musculussearch 94% 593 93%
B Prostaglandin G/H synthase 2 Q05769 (20-604) (PGH2_MOUSE)search Mus musculussearch 94% 593 93%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q05769 (20 - 604) Prostaglandin G/H synthase 2 Mus musculus

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (Q05769) Lamininsearch, Myeloperoxidase, subunit Csearch PF03098: Animal haem peroxidasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (Q05769) heme bindingsearch prostaglandin-endoperoxide synthase activitysearch lipid bindingsearch enzyme bindingsearch peroxidase activitysearch protein homodimerization activitysearch oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygensearch oxidoreductase activitysearch dioxygenase activitysearch metal ion bindingsearch cyclooxygenase pathwaysearch response to oxidative stresssearch inflammatory responsesearch oxidation-reduction processsearch fatty acid biosynthetic processsearch decidualizationsearch response to fructosesearch cellular response to hypoxiasearch response to organic substancesearch cellular response to UVsearch prostaglandin biosynthetic processsearch cellular response to fluid shear stresssearch negative regulation of synaptic transmission, dopaminergicsearch keratinocyte differentiationsearch positive regulation of synaptic transmission, glutamatergicsearch positive regulation of transforming growth factor beta productionsearch response to lithium ionsearch response to organonitrogen compoundsearch embryo implantationsearch negative regulation of cell cyclesearch bone mineralizationsearch regulation of cell proliferationsearch positive regulation of smooth muscle contractionsearch positive regulation of synaptic plasticitysearch negative regulation of smooth muscle contractionsearch response to glucocorticoidsearch positive regulation of NF-kappaB import into nucleussearch response to lipopolysaccharidesearch positive regulation of cell migration involved in sprouting angiogenesissearch positive regulation of fibroblast growth factor productionsearch response to organic cyclic compoundsearch positive regulation of cell deathsearch response to fatty acidsearch positive regulation of smooth muscle cell proliferationsearch negative regulation of cell proliferationsearch sensory perception of painsearch maintenance of blood-brain barriersearch positive regulation of fever generationsearch regulation of blood pressuresearch positive regulation of brown fat cell differentiationsearch ovulationsearch hair cyclesearch response to drugsearch cellular response to ATPsearch response to vitamin Dsearch positive regulation of vascular endothelial growth factor productionsearch response to cytokinesearch positive regulation of apoptotic processsearch memorysearch response to estradiolsearch positive regulation of vasoconstrictionsearch positive regulation of nitric oxide biosynthetic processsearch response to radiationsearch response to tumor necrosis factorsearch response to manganese ionsearch positive regulation of platelet-derived growth factor productionsearch negative regulation of calcium ion transportsearch cellular response to mechanical stimulussearch prostaglandin metabolic processsearch fatty acid metabolic processsearch angiogenesissearch brown fat cell differentiationsearch learningsearch positive regulation of cell proliferationsearch lipid metabolic processsearch neuron projectionsearch caveolasearch intracellular membrane-bounded organellesearch membranesearch endoplasmic reticulum membranesearch organelle membranesearch cytoplasmsearch protein complexsearch endoplasmic reticulumsearch

Chain InterPro annotation
A, B Epidermal growth factor-like domainsearch Haem peroxidasesearch Haem peroxidase, animalsearch Prostaglandin G/H synthase 2search