3tz4 Summary


Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/S-alpha-chloroisocaproate complex with ADP

The structure was published by Tso, S.C., Chuang, J.L., Gui, W.J., Wynn, R.M., Li, J., and Chuang, D.T., in 2013 in a paper entitled "Structures of branched-chain alpha-ketoacid dehydrogenase kinase-inhibitor complexes" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.25 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial. This molecule has the UniProt identifier Q00972 (BCKD_RAT)search. The sample contained 418 residues which is 100% of the natural sequence. Out of 418 residues 310 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Q00972 (1-412) (BCKD_RAT)search Rattus norvegicussearch 93% 418 74%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q00972 (1 - 412) [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Rattus norvegicus

Chain Sequence family (Pfam)
A (Q00972) PF02518: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPasesearch, PF10436: Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (Q00972) [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activitysearch ATP bindingsearch protein kinase activitysearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch kinase activitysearch transferase activitysearch nucleotide bindingsearch mitochondrionsearch mitochondrial alpha-ketoglutarate dehydrogenase complexsearch mitochondrial matrixsearch phosphorylationsearch protein phosphorylationsearch branched-chain amino acid catabolic processsearch

Chain InterPro annotation
A Histidine kinase-like ATPase, C-terminal domainsearch Signal transduction histidine kinase-related protein, C-terminalsearch Signal transduction histidine kinase, coresearch Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminalsearch