› 3tur

X-ray diffraction
1.72Å resolution

Crystal Structure of M. tuberculosis LD-transpeptidase type 2 complexed with a peptidoglycan fragment

Released:
DOI: 10.2210/pdb3tur/pdb
PDB entry 3tur coloured by chain, front view.
PDB entry 3tur coloured by chain, side view.
PDB entry 3tur coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Primary publication:
Targeting the cell wall of Mycobacterium tuberculosis: structure and mechanism of L,D-transpeptidase 2.
Erdemli SB, Gupta R, Bishai WR, Lamichhane G, Amzel LM, Bianchet MA
Structure 20 2103-15 (2012)
PMID: 23103390

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129429 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
L,D-transpeptidase 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 287 amino acids
Theoretical weight: 31.13 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
UniProt:
  • Canonical: O53223 (Residues: 122-408; Coverage: 77%)
Gene names: MT2594, V735_02606, ldtB
Sequence domains:
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand 0JC 8 x 0JC
Ligand DGL 1 x DGL
Ligand 6CL 1 x 6CL
Ligand PT 1 x PT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: I212121
Unit cell:
a: 119.132Å b: 120.829Å c: 122.847Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.198 0.235
Expression system: Escherichia coli

Quick links

Citations

8 review citations

The cell envelope glycoconjugates of Mycobacterium tuberculosis.
Angala et al. (2014)
7 more

9 mentions without citation

Drug Discovery for Mycobacterium tuberculosis Using Structure-Based Computer-Aided Drug Design Approach.
Ejalonibu et al. (2021)
8 more