Crystal Structure of JNK3 complexed with CC-359, a JNK inhibitor for the prevention of ischemia-reperfusion injury
The structure was published by Krenitsky, V.P., Delgado, M., Nadolny, L., et al., Cole, A.G., Bennett, B., and Satoh, Y., in 2012 in a paper entitled "Aminopurine based JNK inhibitors for the prevention of ischemia reperfusion injury." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2011.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Mitogen-activated protein kinase 10. This molecule has the UniProt identifier P53779 (MK10_HUMAN). The sample contained 464 residues which is 100% of the natural sequence. Out of 464 residues 333 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: