3ttj Summary


Crystal Structure of JNK3 complexed with CC-359, a JNK inhibitor for the prevention of ischemia-reperfusion injury

The structure was published by Krenitsky, V.P., Delgado, M., Nadolny, L., et al., Cole, A.G., Bennett, B., and Satoh, Y., in 2012 in a paper entitled "Aminopurine based JNK inhibitors for the prevention of ischemia reperfusion injury." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 10. This molecule has the UniProt identifier P53779 (MK10_HUMAN)search. The sample contained 464 residues which is 100% of the natural sequence. Out of 464 residues 333 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 10 P53779 (1-464) (MK10_HUMAN)search Homo sapienssearch 91% 464 71%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P53779 (1 - 464) Mitogen-activated protein kinase 10 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P53779) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P53779) nucleotide bindingsearch protein kinase activitysearch protein serine/threonine kinase activitysearch JUN kinase activitysearch MAP kinase activitysearch MAP kinase kinase activitysearch protein bindingsearch ATP bindingsearch kinase activitysearch transferase activitysearch transferase activity, transferring phosphorus-containing groupssearch activation of MAPK activitysearch toll-like receptor signaling pathwaysearch MyD88-dependent toll-like receptor signaling pathwaysearch MyD88-independent toll-like receptor signaling pathwaysearch protein phosphorylationsearch signal transductionsearch JNK cascadesearch JUN phosphorylationsearch response to light stimulussearch phosphorylationsearch toll-like receptor 2 signaling pathwaysearch toll-like receptor 3 signaling pathwaysearch toll-like receptor 4 signaling pathwaysearch toll-like receptor 5 signaling pathwaysearch toll-like receptor 9 signaling pathwaysearch toll-like receptor 10 signaling pathwaysearch TRIF-dependent toll-like receptor signaling pathwaysearch Fc-epsilon receptor signaling pathwaysearch toll-like receptor TLR1:TLR2 signaling pathwaysearch toll-like receptor TLR6:TLR2 signaling pathwaysearch regulation of circadian rhythmsearch innate immune responsesearch rhythmic processsearch regulation of sequence-specific DNA binding transcription factor activitysearch stress-activated MAPK cascadesearch nucleussearch nucleoplasmsearch cytoplasmsearch mitochondrionsearch cytosolsearch plasma membranesearch membranesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Serine/threonine-protein kinase, active sitesearch Mitogen-activated protein (MAP) kinase, JNKsearch Protein kinase-like domainsearch